| 1. Round | 09/01/2021 | Mazatlán FC | - | Club Necaxa | 3:2 | ||||
| 2. Round | 16/01/2021 | Club Necaxa | - | Atlético San Luis | 1:0 | ||||
| 3. Round | 24/01/2021 | Deportivo Toluca | - | Club Necaxa | 2:0 | ||||
| 4. Round | 29/01/2021 | UANL Tigres | - | Club Necaxa | 1:1 | ||||
| 5. Round | 06/02/2021 | Club Necaxa | - | Cruz Azul | 0:2 | ||||
| 6. Round | 14/02/2021 | Deportivo Guadalajara | - | Club Necaxa | 2:2 | ||||
| 7. Round | 20/02/2021 | Club Necaxa | - | CF Monterrey | 1:1 | ||||
| 8. Round | 27/02/2021 | Puebla FC | - | Club Necaxa | 1:0 | ||||
| 9. Round | 05/03/2021 | Club Necaxa | - | CF Pachuca | 2:2 | ||||
| 10. Round | 08/03/2021 | Santos Laguna | - | Club Necaxa | 3:1 | ||||
| 11. Round | 16/03/2021 | Club León | - | Club Necaxa | 3:1 | ||||
| 12. Round | 20/03/2021 | Club Necaxa | - | FC Juárez | 1:0 | ||||
| 13. Round | 04/04/2021 | CF América | - | Club Necaxa | 2:1 |  |
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| 14. Round | 10/04/2021 | Club Necaxa | - | Pumas UNAM | 0:1 | ||||
| 15. Round | 17/04/2021 | Club Necaxa | - | Gallos Blancos | 0:0 | ||||
| 16. Round | 24/04/2021 | Club Tijuana | - | Club Necaxa | 1:0 | ||||
| 17. Round | 01/05/2021 | Club Necaxa | - | Atlas Guadalajara | 1:5 |
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