| 1. Round | 19/07/2021 | Deportivo Toluca [Women] | - | Atlas Guadalajara [Women] | 2:3 | ||||
| 2. Round | 24/07/2021 | Atlas Guadalajara [Women] | - | Gallos Blancos [Women] | 2:1 | ||||
| 4. Round | 07/08/2021 | Atlas Guadalajara [Women] | - | UANL Tigres [Women] | 0:4 | ||||
| 5. Round | 17/08/2021 | Santos Laguna [Women] | - | Atlas Guadalajara [Women] | 2:2 |  |
|||
| 6. Round | 22/08/2021 | Atlas Guadalajara [Women] | - | Pumas UNAM [Women] | 0:0 | ||||
| 8. Round | 05/09/2021 | Deportivo Guadalajara [Women] | - | Atlas Guadalajara [Women] | 1:0 |  |
|||
| 10. Round | 26/09/2021 | Atlas Guadalajara [Women] | - | Cruz Azul [Women] | 3:0 | ||||
| 13. Round | 19/10/2021 | Club León [Women] | - | Atlas Guadalajara [Women] | 0:1 | ||||
| 14. Round | 30/10/2021 | Mazatlán FC [Women] | - | Atlas Guadalajara [Women] | 0:3 | ||||
| 16. Round | 13/11/2021 | Atlas Guadalajara [Women] | - | CF Pachuca [Women] | 2:1 | ||||
| 17. Round | 21/11/2021 | Puebla FC [Women] | - | Atlas Guadalajara [Women] | 0:4 | |
Mexico