| 1. Round | 06/11/2021 | Olympiakos Piraeus II | - | PAOK Saloniki II | 3:1 | ||||
| 3. Round | 20/11/2021 | AEP Iraklis FC | - | PAOK Saloniki II | 0:0 | ||||
| 4. Round | 24/11/2021 | PAOK Saloniki II | - | Veria FC | 1:2 | ||||
| 7. Round | 11/12/2021 | Pierikos Katerini | - | PAOK Saloniki II | 0:0 | ||||
| 8. Round | 15/12/2021 | PAOK Saloniki II | - | Xanthi FC | 0:1 | ||||
| 9. Round | 19/12/2021 | Thesprotos | - | PAOK Saloniki II | 1:1 |  |
|||
| 10. Round | 09/02/2022 | PAOK Saloniki II | - | AO Kavala | 1:1 | ||||
| 18. Round | 13/02/2022 | PAOK Saloniki II | - | Olympiakos Piraeus II | 1:0 | |
|||
| 19. Round | 16/02/2022 | Panserraikos | - | PAOK Saloniki II | 1:2 | ||||
| 20. Round | 20/02/2022 | PAOK Saloniki II | - | AEP Iraklis FC | 0:0 | ||||
| 21. Round | 26/02/2022 | Veria FC | - | PAOK Saloniki II | 2:1 |  |
|
||
| 13. Round | 02/03/2022 | Olympiakos Volou | - | PAOK Saloniki II | 3:1 | ||||
| 30. Round | 10/04/2022 | PAOK Saloniki II | - | Olympiakos Volou | 2:1 | ||||
| 32. Round | 16/04/2022 | AO Trikala | - | PAOK Saloniki II | 0:6 | |
|||
| 33. Round | 27/04/2022 | PAOK Saloniki II | - | AE Lárissa | 2:0 | ||||
| 34. Round | 01/05/2022 | Apollon Lárissa | - | PAOK Saloniki II | 2:1 |
Greece