| 1. Round | 05/09/2021 | CD Eldense | - | CF Intercity | 0:0 | ||||
| 2. Round | 12/09/2021 | CF Intercity | - | Hércules CF | 1:2 |  |
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| 4. Round | 26/09/2021 | CF Intercity | - | UD Melilla | 0:0 | ||||
| 5. Round | 03/10/2021 | Águilas FC | - | CF Intercity | 1:2 | ||||
| 6. Round | 10/10/2021 | CF Intercity | - | Atlético Mancha Real | 1:0 | ||||
| 7. Round | 17/10/2021 | CD Toledo | - | CF Intercity | 0:1 | ||||
| 8. Round | 24/10/2021 | CF Intercity | - | CD Marchamalo | 3:0 | ||||
| 9. Round | 31/10/2021 | Recreativo Granada | - | CF Intercity | 3:3 | ||||
| 10. Round | 07/11/2021 | CF Intercity | - | CS Puertollano CF | 4:0 | ||||
| 11. Round | 14/11/2021 | CF Intercity | - | Mar Menor CF | 3:0 |  |
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| 12. Round | 21/11/2021 | UD Alzira | - | CF Intercity | 0:0 | |
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| 13. Round | 28/11/2021 | CF Intercity | - | UD Socuéllamos | 1:0 | ||||
| 14. Round | 05/12/2021 | CA Pulpileño | - | CF Intercity | 1:1 | |
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| 15. Round | 12/12/2021 | CF Intercity | - | Levante UD B | 2:0 | |
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| 16. Round | 19/12/2021 | CD El Ejido 2012 | - | CF Intercity | 0:1 | |
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| 18. Round | 23/01/2022 | CF Intercity | - | CD Eldense | 1:1 | ||||
| 19. Round | 30/01/2022 | Hércules CF | - | CF Intercity | 0:1 | |
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| 34. Round | 15/05/2022 | CF La Nucía | - | CF Intercity | 0:0 |
Spain