1. Round | 01/08/2021 | Real Estelí FC | - | H&H Export Sébaco | 4:0 | ||||
2. Round | 08/08/2021 | Real Estelí FC | - | Real Madriz | 3:0 | ||||
3. Round | 16/08/2021 | Managua FC | - | Real Estelí FC | 3:0 | ||||
4. Round | 21/08/2021 | Juventus Managua | - | Real Estelí FC | 1:3 | ||||
5. Round | 30/08/2021 | Real Estelí FC | - | ART Municipal Jalapa | 2:0 | ||||
6. Round | 02/09/2021 | Real Estelí FC | - | UNAN Managua | 4:1 | ||||
9. Round | 26/09/2021 | Club Deportivo Ocotal | - | Real Estelí FC | 1:2 |