| 1. Round | 16/07/2022 | FK Orenburg | - | Krylia Sovetov | 2:4 | ||||
| 2. Round | 23/07/2022 | FK Orenburg | - | FK Ural | 3:0 |  |
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| 3. Round | 31/07/2022 | Spartak Moskva | - | FK Orenburg | 4:1 | ||||
| 5. Round | 14/08/2022 | FK Orenburg | - | Torpedo Moskva | 1:0 | ||||
| 7. Round | 28/08/2022 | Lokomotiv Moskva | - | FK Orenburg | 5:1 | |
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| 8. Round | 03/09/2022 | FK Orenburg | - | FK Khimki | 3:1 | |
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| 9. Round | 11/09/2022 | Zenit St. Petersburg | - | FK Orenburg | 8:0 | ||||
| 10. Round | 18/09/2022 | FK Nizhny Novgorod | - | FK Orenburg | 0:2 | ||||
| 11. Round | 01/10/2022 | FK Orenburg | - | FK Sochi | 4:1 | |
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| 12. Round | 09/10/2022 | FK Orenburg | - | Akhmat Grozny | 2:1 | |
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| 13. Round | 15/10/2022 | Dinamo Moskva | - | FK Orenburg | 3:2 | |
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| 14. Round | 23/10/2022 | FK Orenburg | - | CSKA Moskva | 2:2 | |
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| 15. Round | 28/10/2022 | FK Orenburg | - | Fakel Voronezh | 4:1 | |
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| 16. Round | 04/11/2022 | FK Khimki | - | FK Orenburg | 2:0 | ||||
| 17. Round | 13/11/2022 | FK Orenburg | - | FK Krasnodar | 5:1 | |
Ukraine