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| 04/11/2022 | 16:00 | FK Khimki | - | FK Orenburg | 2:0 (0:0) | |
| 05/11/2022 | 11:00 | FK Sochi | - | Spartak Moskva | 1:1 (1:1) | |
| 13:30 | Fakel Voronezh | - | FK Krasnodar | 3:3 (1:2) | ||
| 13:30 | Zenit St. Petersburg | - | Akhmat Grozny | 1:2 (0:2) | ||
| 16:00 | CSKA Moskva | - | FK Nizhny Novgorod | 0:1 (0:0) | ||
| 06/11/2022 | 11:00 | FK Ural | - | Lokomotiv Moskva | 2:2 (0:1) | |
| 13:30 | Torpedo Moskva | - | Krylia Sovetov | 0:2 (0:1) | ||
| 16:00 | FK Rostov | - | Dinamo Moskva | 2:1 (0:0) |
| » Tables | Home | Away | First round | Second round |
| # | Team | M. | W | D | L | goals | Dif. | Pt. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Zenit St. Petersburg | 16 | 12 | 3 | 1 | 45:7 | 38 | 39 |
| 2 |
|
Spartak Moskva | 16 | 10 | 3 | 3 | 38:17 | 21 | 33 |
| 3 |
|
FK Rostov | 16 | 9 | 5 | 2 | 29:22 | 7 | 32 |
| 4 |
|
CSKA Moskva | 16 | 8 | 5 | 3 | 29:16 | 13 | 29 |
| 5 |
|
Dinamo Moskva | 16 | 7 | 5 | 4 | 31:20 | 11 | 26 |
| 6 |
|
Akhmat Grozny | 16 | 8 | 2 | 6 | 25:24 | 1 | 26 |
| 7 |
|
FK Krasnodar | 16 | 7 | 4 | 5 | 30:24 | 6 | 25 |
| 8 |
|
FK Sochi | 16 | 6 | 4 | 6 | 25:32 | -7 | 22 |
| 9 |
|
FK Orenburg | 16 | 7 | 1 | 8 | 28:36 | -8 | 22 |
| 10 |
|
Krylia Sovetov | 16 | 5 | 5 | 6 | 19:22 | -3 | 20 |
| 11 |
|
FK Ural | 16 | 5 | 3 | 8 | 19:28 | -9 | 18 |
| 12 |
|
FK Nizhny Novgorod | 16 | 4 | 4 | 8 | 19:27 | -8 | 16 |
| 13 |
|
Fakel Voronezh | 16 | 1 | 10 | 5 | 21:31 | -10 | 13 |
| 14 |
|
Lokomotiv Moskva | 16 | 3 | 4 | 9 | 19:32 | -13 | 13 |
| 15 |
|
FK Khimki | 16 | 3 | 3 | 10 | 16:34 | -18 | 12 |
| 16 |
|
Torpedo Moskva | 16 | 1 | 3 | 12 | 7:28 | -21 | 6 |
| Playoffs | |
| Relegation |
