| 4. Round | 26/08/2022 | FK Mladá Boleslav [Youth B] | - | Banik Ostrava [Youth B] | 3:2 | ||||
| 8. Round | 30/08/2022 | AC Sparta Praha [Youth B] | - | FK Mladá Boleslav [Youth B] | 7:0 | ||||
| 5. Round | 03/09/2022 | Dynamo České Budějovice [Youth B] | - | FK Mladá Boleslav [Youth B] | 1:0 | ||||
| 7. Round | 17/09/2022 | 1. FC Slovácko [Youth B] | - | FK Mladá Boleslav [Youth B] | 0:1 | ||||
| 10. Round | 08/10/2022 | FC Zbrojovka Brno [Youth B] | - | FK Mladá Boleslav [Youth B] | 5:0 | ||||
| 11. Round | 14/10/2022 | FK Mladá Boleslav [Youth B] | - | Slavia Praha [Youth B] | 1:4 | ||||
| 12. Round | 22/10/2022 | FK Dukla Praha [Youth B] | - | FK Mladá Boleslav [Youth B] | 3:1 | ||||
| 13. Round | 28/10/2022 | FK Mladá Boleslav [Youth B] | - | MFK Karviná [Youth B] | 3:2 | ||||
| 14. Round | 05/11/2022 | FK Příbram [Youth B] | - | FK Mladá Boleslav [Youth B] | 1:1 |  |
Czech Republic