| 5. Round | 02/08/2015 | Deportivo Santaní | - | Club Rubio Ñu | 1:2 | ||||
| 6. Round | 09/08/2015 | San Lorenzo | - | Club Rubio Ñu | 1:1 | ||||
| 7. Round | 15/08/2015 | Club Rubio Ñu | - | General Díaz | 1:1 |  |
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| 8. Round | 23/08/2015 | Club Olimpia | - | Club Rubio Ñu | 2:1 | ||||
| 9. Round | 30/08/2015 | Club Rubio Ñu | - | Sportivo Luqueño | 2:2 | ||||
| 10. Round | 06/09/2015 | Libertad | - | Club Rubio Ñu | 2:1 | ||||
| 11. Round | 14/09/2015 | Club Rubio Ñu | - | Guaraní | 0:1 | ||||
| 12. Round | 20/09/2015 | Club Rubio Ñu | - | Club Nacional | 1:1 | ||||
| 13. Round | 26/09/2015 | Sol de América | - | Club Rubio Ñu | 4:1 | ||||
| 14. Round | 03/10/2015 | Club Rubio Ñu | - | Cerro Porteño | 1:2 | ||||
| 16. Round | 23/10/2015 | Club Rubio Ñu | - | Deportivo Santaní | 1:2 | ||||
| 17. Round | 31/10/2015 | Club Rubio Ñu | - | San Lorenzo | 3:0 | ||||
| 18. Round | 03/11/2015 | General Díaz | - | Club Rubio Ñu | 1:2 | ||||
| 19. Round | 08/11/2015 | Club Rubio Ñu | - | Club Olimpia | 1:3 | |
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| 20. Round | 22/11/2015 | Sportivo Luqueño | - | Club Rubio Ñu | 2:0 |
Paraguay