| Group B | 10/06/2022 | River Plate | - | Cerrito | 3:0 |  |
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| Group B | 18/06/2022 | Nacional | - | River Plate | 3:0 | ||||
| Group B | 26/06/2022 | River Plate | - | Boston River | 0:1 | ||||
| Group B | 10/07/2022 | Danubio | - | River Plate | 1:3 | ||||
| Group B | 15/07/2022 | Plaza Colonia | - | River Plate | 0:0 | ||||
| Group B | 21/07/2022 | River Plate | - | Defensor Sporting | 1:1 | ||||
| Group B | 25/07/2022 | Cerro Largo | - | River Plate | 0:0 |
Paraguay