| Round of 16 | 17/02/2022 | Deportivo Saprissa | - | Pumas UNAM | 2:2 |  |
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| Round of 16 | 24/02/2022 | Pumas UNAM | - | Deportivo Saprissa | 4:1 | ||||
| Quarter-finals | 10/03/2022 | New England Revolution | - | Pumas UNAM | 3:0 | ||||
| Quarter-finals | 17/03/2022 | Pumas UNAM | - | New England Revolution | 3:0 pso | ||||
| Semi-finals | 06/04/2022 | Pumas UNAM | - | Cruz Azul | 2:1 | ||||
| Semi-finals | 13/04/2022 | Cruz Azul | - | Pumas UNAM | 0:0 | ||||
| Final | 28/04/2022 | Pumas UNAM | - | Seattle Sounders | 2:2 |  |
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| Final | 05/05/2022 | Seattle Sounders | - | Pumas UNAM | 3:0 |
Ecuador