| 3. Round | 26/07/2022 | Resistencia SC | - | Guaraní | 0:0 | ||||
| 4. Round | 31/07/2022 | Libertad | - | Resistencia SC | 4:0 | ||||
| 6. Round | 15/08/2022 | Tacuary | - | Resistencia SC | 1:1 | ||||
| 7. Round | 19/08/2022 | Resistencia SC | - | Sportivo Ameliano | 2:1 | ||||
| 8. Round | 27/08/2022 | Club Olimpia | - | Resistencia SC | 1:1 |  |
|||
| 9. Round | 03/09/2022 | Resistencia SC | - | General Caballero DJLM | 0:0 | ||||
| 10. Round | 10/09/2022 | Resistencia SC | - | Cerro Porteño | 0:2 | ||||
| 11. Round | 16/09/2022 | 12 de Octubre de Itauguá | - | Resistencia SC | 1:0 | ||||
| 14. Round | 03/10/2022 | Guaraní | - | Resistencia SC | 0:1 | ||||
| 15. Round | 06/10/2022 | Resistencia SC | - | Libertad | 1:0 | ||||
| 16. Round | 10/10/2022 | Guaireña FC | - | Resistencia SC | 3:2 | ||||
| 17. Round | 15/10/2022 | Resistencia SC | - | Tacuary | 0:3 | ||||
| 19. Round | 27/10/2022 | Resistencia SC | - | Club Olimpia | 1:6 | ||||
| 20. Round | 01/11/2022 | General Caballero DJLM | - | Resistencia SC | 1:0 | |
|||
| 21. Round | 07/11/2022 | Cerro Porteño | - | Resistencia SC | 1:0 | |
Paraguay