1. Round | 08/08/2021 | Atlético Chiriquí | - | San Francisco FC | 1:1 | ||||
2. Round | 14/08/2021 | San Francisco FC | - | UD Universitario | 0:1 | ||||
3. Round | 22/08/2021 | Independiente de La Chorrera | - | San Francisco FC | 2:0 | ||||
4. Round | 28/08/2021 | San Francisco FC | - | Herrera FC | 1:3 | ||||
5. Round | 05/09/2021 | Veraguas Club Deportivo | - | San Francisco FC | 1:0 | ||||
6. Round | 12/09/2021 | San Francisco FC | - | Tauro FC | 1:3 | ||||
7. Round | 19/09/2021 | Plaza Amador | - | San Francisco FC | 1:1 | ||||
8. Round | 26/09/2021 | Deportivo del Este | - | San Francisco FC | 0:0 | ||||
9. Round | 02/10/2021 | San Francisco FC | - | Alianza | 0:1 | ||||
10. Round | 10/10/2021 | Sporting San Miguelito | - | San Francisco FC | 1:1 | ||||
15. Round | 13/11/2021 | Herrera FC | - | San Francisco FC | 2:1 | ||||
16. Round | 20/11/2021 | San Francisco FC | - | Veraguas Club Deportivo | 0:1 |