| 1. Round | 19/02/2020 | Valledupar FC | - | Deportes Quindío | 0:2 | ||||
| 1. Round | 05/03/2020 | Deportes Quindío | - | Valledupar FC | 2:0 |  |
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| 2. Round | 25/09/2020 | Fortaleza FC | - | Deportes Quindío | 0:1 | |
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| 2. Round | 01/10/2020 | Deportes Quindío | - | Fortaleza FC | 1:0 | ||||
| 3. Round | 21/10/2020 | Jaguares de Córdoba | - | Deportes Quindío | 0:1 | ||||
| 3. Round | 29/10/2020 | Deportes Quindío | - | Jaguares de Córdoba | 4:3 pso | ||||
| Round of 16 | 18/11/2020 | Deportes Quindío | - | Deportivo Cali | 5:4 pso | ||||
| Quarter-finals | 13/01/2021 | Deportes Quindío | - | Alianza Petrolera | 2:0 |
Colombia