1. Round | 17/07/2022 | General Caballero DJLM | - | Club Nacional | 1:2 | ||||
2. Round | 21/07/2022 | Club Nacional | - | Resistencia SC | 1:1 | ||||
7. Round | 21/08/2022 | Club Nacional | - | Libertad | 0:2 | ||||
11. Round | 16/09/2022 | Club Nacional | - | Club Olimpia | 1:1 | ||||
12. Round | 19/09/2022 | Club Nacional | - | General Caballero DJLM | 1:0 | ||||
13. Round | 25/09/2022 | Resistencia SC | - | Club Nacional | 0:1 | ||||
15. Round | 06/10/2022 | Sol de América | - | Club Nacional | 2:3 | ||||
16. Round | 10/10/2022 | Club Nacional | - | Cerro Porteño | 0:0 | ||||
17. Round | 17/10/2022 | Club Nacional | - | Guaraní | 2:0 | ||||
18. Round | 23/10/2022 | Libertad | - | Club Nacional | 0:1 | ||||
19. Round | 27/10/2022 | Club Nacional | - | Guaireña FC | 3:0 | ||||
20. Round | 31/10/2022 | Tacuary | - | Club Nacional | 2:1 |