| 1. Round | 12/08/2015 | Liga de Loja | - | Santa Fe | 0:0 | ||||
| 1. Round | 21/08/2015 | Santa Fe | - | Liga de Loja | 3:0 |  |
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| 2. Round | 27/08/2015 | Nacional | - | Santa Fe | 0:2 | |
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| 2. Round | 17/09/2015 | Santa Fe | - | Nacional | 0:1 | ||||
| Round of 16 | 23/09/2015 | Emelec | - | Santa Fe | 2:1 | ||||
| Round of 16 | 30/09/2015 | Santa Fe | - | Emelec | 1:0 | |
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| Quarter-finals | 23/10/2015 | Independiente | - | Santa Fe | 0:1 | ||||
| Quarter-finals | 30/10/2015 | Santa Fe | - | Independiente | 1:1 | ||||
| Semi-finals | 04/11/2015 | Sportivo Luqueño | - | Santa Fe | 1:1 | ||||
| Semi-finals | 26/11/2015 | Santa Fe | - | Sportivo Luqueño | 0:0 |  |
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| Final | 03/12/2015 | Huracán | - | Santa Fe | 0:0 | ||||
| Final | 10/12/2015 | Santa Fe | - | Huracán | 3:1 pso |
Colombia