| 1. Round | 16/07/2021 | Gallos Blancos [Women] | - | CF Monterrey [Women] | 1:1 | ||||
| 2. Round | 25/07/2021 | CF Monterrey [Women] | - | FC Juárez [Women] | 2:0 | ||||
| 4. Round | 10/08/2021 | CF Monterrey [Women] | - | Puebla FC [Women] | 2:0 | ||||
| 6. Round | 24/08/2021 | CF Monterrey [Women] | - | Deportivo Toluca [Women] | 2:0 | ||||
| 9. Round | 12/09/2021 | CF Monterrey [Women] | - | Club Tijuana [Women] | 4:0 | ||||
| 10. Round | 27/09/2021 | Santos Laguna [Women] | - | CF Monterrey [Women] | 2:2 | ||||
| 11. Round | 05/10/2021 | CF Monterrey [Women] | - | Club León [Women] | 3:1 | ||||
| 12. Round | 10/10/2021 | UANL Tigres [Women] | - | CF Monterrey [Women] | 2:1 |  |
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| 15. Round | 07/11/2021 | Atlético San Luis [Women] | - | CF Monterrey [Women] | 0:3 |  |
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| 16. Round | 16/11/2021 | CF Monterrey [Women] | - | Deportivo Guadalajara [Women] | 2:1 | ||||
| 17. Round | 20/11/2021 | CF Monterrey [Women] | - | Cruz Azul [Women] | 5:0 |
Mexico