| 1. Round | 01/08/2022 | Liverpool | - | Defensor Sporting | 1:3 | ||||
| 2. Round | 07/08/2022 | Defensor Sporting | - | Peñarol | 2:3 | ||||
| 5. Round | 28/08/2022 | Plaza Colonia | - | Defensor Sporting | 0:1 | ||||
| 7. Round | 11/09/2022 | River Plate | - | Defensor Sporting | 0:1 | ||||
| 10. Round | 26/09/2022 | Cerrito | - | Defensor Sporting | 1:2 | ||||
| 12. Round | 08/10/2022 | Nacional | - | Defensor Sporting | 1:1 |
Uruguay