| 2. Round | 05/03/2022 | CF Montréal | - | Philadelphia Union | 1:2 | ||||
| 2. Round | 12/03/2022 | New York City FC | - | CF Montréal | 4:1 |  |
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| 2. Round | 19/03/2022 | Atlanta United FC | - | CF Montréal | 3:3 | ||||
| 3. Round | 02/04/2022 | FC Cincinnati | - | CF Montréal | 3:4 | ||||
| 3. Round | 30/04/2022 | CF Montréal | - | Atlanta United FC | 2:1 | ||||
| 4. Round | 07/05/2022 | CF Montréal | - | Orlando City | 4:1 | |
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| 4. Round | 22/05/2022 | CF Montréal | - | Real Salt Lake | 1:2 | ||||
| 5. Round | 19/06/2022 | CF Montréal | - | Austin FC | 0:1 | ||||
| 5. Round | 26/06/2022 | CF Montréal | - | Charlotte FC | 2:1 | ||||
| 5. Round | 30/06/2022 | Seattle Sounders | - | CF Montréal | 1:2 | ||||
| 6. Round | 10/07/2022 | CF Montréal | - | Sporting Kansas City | 1:2 | ||||
| 6. Round | 17/07/2022 | CF Montréal | - | Toronto FC | 1:0 |  |
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| 7. Round | 04/08/2022 | Columbus Crew | - | CF Montréal | 1:2 | ||||
| 7. Round | 14/08/2022 | Houston Dynamo | - | CF Montréal | 2:3 | ||||
| 7. Round | 01/09/2022 | CF Montréal | - | New York RB | 0:1 | ||||
| 8. Round | 10/09/2022 | CF Montréal | - | Columbus Crew | 2:2 | |
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| 8. Round | 14/09/2022 | CF Montréal | - | Chicago Fire | 3:2 | |
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| 9. Round | 02/10/2022 | CF Montréal | - | D.C. United | 1:0 |
Haiti
France