| 1. Round | 18/09/2021 | Leones Negros II | - | Gavilanes de Matamoros | 2:2 | ||||
| 2. Round | 25/09/2021 | Gavilanes de Matamoros | - | Coras de Nayarit | 0:0 |  |
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| 3. Round | 02/10/2021 | Mineros de Fresnillo FC | - | Gavilanes de Matamoros | 0:0 | ||||
| 5. Round | 14/10/2021 | Alacranes de Durango | - | Gavilanes de Matamoros | 1:0 | ||||
| 6. Round | 16/10/2021 | Gavilanes de Matamoros | - | Cimarrones de Sonora II | 2:1 |  |
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| 8. Round | 30/10/2021 | Gavilanes de Matamoros | - | Tritones Vallarta | 4:0 | ||||
| 9. Round | 06/11/2021 | Catedráticos Elite | - | Gavilanes de Matamoros | 1:3 | ||||
| 10. Round | 11/11/2021 | Gavilanes de Matamoros | - | Correcaminos UAT II | 2:0 | ||||
| 11. Round | 13/11/2021 | Gavilanes de Matamoros | - | Mazorqueros | 0:3 | ||||
| 12. Round | 20/11/2021 | Tecos Fútbol Club | - | Gavilanes de Matamoros | 2:0 | ||||
| 13. Round | 27/11/2021 | Gavilanes de Matamoros | - | Colima FC | 3:1 |
Mexico