| Copa Sudamericana | Matches | W | D | L |  |
 |
 |
| home | 2 | 2 | - | - | 5 | - | - |
| away | 1 | - | - | 1 | 4 | - | - |
| overall | 3 | 2 | - | 1 | 9 | - | - |
| Copa Sudamericana | Home | - | Guest | |
|
|
Results |
| 29/04/21 | Rosario Central | - | San Lorenzo | 2 | - | - | 2:0 |
| 20/05/21 | Rosario Central | - | Huachipato | 3 | - | - | 5:0 |
| 18/08/21 | Red Bull Bragantino | - | Rosario Central | 4 | - | - | 1:0 |
Uruguay