| Copa Sudamericana | Matches | W | D | L |  |
 |
 |
| home | - | - | - | - | - | - | - |
| away | 1 | - | - | 1 | 2 | - | - |
| overall | 1 | - | - | 1 | 2 | - | - |
| Primera División | Matches | W | D | L | |
|
|
| home | 7 | 2 | 3 | 2 | 15 | 1 | - |
| away | 10 | 2 | 5 | 3 | 28 | - | 3 |
| overall | 17 | 4 | 8 | 5 | 43 | 1 | 3 |
| Copa Sudamericana | Home | - | Guest | |
|
|
Results |
| 09/04/21 | River Plate | - | Guaireña FC | 2 | - | - | 4:2 |
| Primera División | Home | - | Guest | |
|
|
Results |
| 07/08/20 | Guaireña FC | - | Club Nacional | 2 | 1 | - | 0:0 |
| 13/09/20 | Guaireña FC | - | San Lorenzo | 1 | - | - | 4:0 |
| 25/10/20 | Guaireña FC | - | Club Olimpia | 3 | - | - | 2:1 |
| 28/12/20 | Guaireña FC | - | Guaraní | 4 | - | - | 0:1 |
| 21/02/21 | Cerro Porteño | - | Guaireña FC | 1 | - | - | 2:2 |
| 14/03/21 | Guaraní | - | Guaireña FC | 2 | - | - | 0:3 |
| 12/04/21 | Libertad | - | Guaireña FC | 3 | - | - | 2:1 |
| 12/09/21 | Guaraní | - | Guaireña FC | 4 | - | - | 3:0 |
| 11/04/22 | Tacuary | - | Guaireña FC | 1 | - | 1 | 0:1 |
| 27/06/22 | Sportivo Ameliano | - | Guaireña FC | 3 | - | - | 2:2 |
| 15/10/22 | 12 de Octubre de Itauguá | - | Guaireña FC | 3 | - | 1 | 0:0 |
| 27/02/23 | Club Olimpia | - | Guaireña FC | 3 | - | - | 1:1 |
| 12/04/23 | Club Nacional | - | Guaireña FC | 4 | - | - | 2:2 |
| 17/05/23 | Guaireña FC | - | Libertad | 2 | - | - | 0:2 |
| 12/09/23 | Resistencia SC | - | Guaireña FC | 4 | - | 1 | 1:0 |
| 22/10/23 | Guaireña FC | - | Club Nacional | - | - | - | 0:0 |
| 07/11/23 | Guaireña FC | - | Sportivo Ameliano | 3 | - | - | 2:2 |
Paraguay