| Primera División | Matches | W | D | L |  |
 |
 |
| home | 11 | 3 | 4 | 4 | 20 | 1 | 1 |
| away | 5 | - | 4 | 1 | 14 | - | - |
| overall | 16 | 3 | 8 | 5 | 34 | 1 | 1 |
| Primera División | Home | - | Guest | |
|
|
Results |
| 08/01/17 | UANL Tigres | - | Santos Laguna | 2 | - | - | 0:0 |
| 26/02/18 | Santos Laguna | - | Cruz Azul | 2 | - | - | 2:0 |
| 23/07/18 | Santos Laguna | - | Lobos BUAP | 2 | - | - | 2:1 |
| 23/08/18 | Club Tijuana | - | Santos Laguna | 1 | - | - | 2:2 |
| 08/04/19 | Santos Laguna | - | CF Pachuca | 1 | 1 | - | 0:0 |
| 16/09/19 | Santos Laguna | - | CF Pachuca | 1 | - | - | 2:2 |
| 02/02/20 | Santos Laguna | - | Pumas UNAM | 3 | - | - | 1:1 |
| 17/08/20 | Santos Laguna | - | Atlas Guadalajara | 1 | - | - | 0:0 |
| 03/11/20 | Club León | - | Santos Laguna | 5 | - | - | 2:1 |
| 22/03/21 | Santos Laguna | - | Club León | 1 | - | - | 1:2 |
| 17/10/21 | CF Pachuca | - | Santos Laguna | 3 | - | - | 1:1 |
| 09/01/23 | Santos Laguna | - | UANL Tigres | 1 | - | 1 | 0:3 |
| 19/02/23 | Atlético San Luis | - | Santos Laguna | 3 | - | - | 1:1 |
| 27/08/23 | Santos Laguna | - | Deportivo Guadalajara | 6 | - | - | 2:1 |
| 25/09/23 | Santos Laguna | - | Club Necaxa | - | - | - | 2:5 |
| 11/02/24 | Santos Laguna | - | UANL Tigres | 2 | - | - | 0:3 |
Mexico