 |
 |
|
|
| 1st(1st leg) | KS Besëlidhja Lezhë | - | FK Partizani | 0:1 | ||
| 2nd (2nd leg) | FK Partizani | - | KS Besëlidhja Lezhë | 2:0 (0:0) | ||
| 1st(1st leg): 03/11/2021 13:00 | 2nd (2nd leg): 17/11/2021 12:30 | Winner: FK Partizani | ||||
| 1st(1st leg) | KS Korabi Peshkopi | - | KF Teuta Durrës | 0:1 | ||
| 2nd (2nd leg) | KF Teuta Durrës | - | KS Korabi Peshkopi | 2:0 (1:0) | ||
| 1st(1st leg): 03/11/2021 13:00 | 2nd (2nd leg): 17/11/2021 12:30 | Winner: KF Teuta Durrës | ||||
| 1st(1st leg) | KF Bylis Ballsh | - | KF Skënderbeu | 1:1 | ||
| 2nd (2nd leg) | KF Skënderbeu | - | KF Bylis Ballsh | 4:3 (2:1, 2:2, 2:2) pso | ||
| 1st(1st leg): 03/11/2021 13:00 | 2nd (2nd leg): 17/11/2021 12:30 | Winner: KF Skënderbeu | ||||
| 1st(1st leg) | KS Pogradeci | - | FK Vllaznia | 0:2 | ||
| 2nd (2nd leg) | FK Vllaznia | - | KS Pogradeci | 6:1 (6:0) | ||
| 1st(1st leg): 03/11/2021 13:00 | 2nd (2nd leg): 17/11/2021 12:30 | Winner: FK Vllaznia | ||||
| 1st(1st leg) | FK Tomori Berat | - | KF Laçi | 0:1 | ||
| 2nd (2nd leg) | KF Laçi | - | FK Tomori Berat | 1:1 (0:1) | ||
| 1st(1st leg): 03/11/2021 13:00 | 2nd (2nd leg): 17/11/2021 12:30 | Winner: KF Laçi | ||||
| 1st(1st leg) | Flamurtari Vlorë | - | KS Kastrioti | 0:0 | ||
| 2nd (2nd leg) | KS Kastrioti | - | Flamurtari Vlorë | 2:4 (1:1) | ||
| 1st(1st leg): 03/11/2021 13:00 | 2nd (2nd leg): 17/11/2021 12:30 | Winner: Flamurtari Vlorë | ||||
| 1st(1st leg) | Egnatia Rrogozhine | - | FK Kukësi | 3:1 | ||
| 2nd (2nd leg) | FK Kukësi | - | Egnatia Rrogozhine | 1:0 (1:0) | ||
| 1st(1st leg): 03/11/2021 13:00 | 2nd (2nd leg): 17/11/2021 12:30 | Winner: Egnatia Rrogozhine | ||||
| 1st(1st leg) | Dinamo Tiranë | - | KF Tiranë | 2:0 | ||
| 2nd (2nd leg) | KF Tiranë | - | Dinamo Tiranë | 7:8 (1:0, 2:0, 2:0) pso | ||
| 1st(1st leg): 03/11/2021 15:45 | 2nd (2nd leg): 18/11/2021 18:45 | Winner: Dinamo Tiranë | ||||
