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| 17/01/2022 | 18:30 | KV Kortrijk II | - | Royal Excel Mouscron II | 2:2 (2:1) | |
| 19:00 | Lierse Kempenzonen II | - | SK Beveren II | 1:3 (0:2) | ||
| 19:00 | SK Deinze II | - | K Beerschot VA II | 1:6 (1:2) | ||
| 19:00 | Lommel SK II | - | Excelsior Virton II | 2:1 (1:0) | ||
| 19:00 | KVC Westerlo II | - | RFC Seraing II | 2:0 (1:0) | ||
| 28/02/2022 | 19:00 | Union St. Gilloise II | - | KV Oostende II | 3:3 | |
| 19:30 | RWDM Brussels FC II | - | KAS Eupen II | 1:5 |
| » Tables | Home | Away | First round | Second round |
| # | Team | M. | W | D | L | goals | Dif. | Pt. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
KAS Eupen II | 15 | 11 | 1 | 3 | 38:17 | 21 | 34 |
| 2 |
|
K Beerschot VA II | 15 | 10 | 3 | 2 | 38:15 | 23 | 33 |
| 3 |
|
KV Oostende II | 15 | 7 | 6 | 2 | 36:20 | 16 | 27 |
| 4 |
|
RWDM Brussels FC II | 15 | 8 | 2 | 5 | 39:31 | 8 | 26 |
| 5 |
|
SK Beveren II | 15 | 8 | 1 | 6 | 28:15 | 13 | 25 |
| 6 |
|
Royal Excel Mouscron II | 15 | 7 | 3 | 5 | 29:16 | 13 | 24 |
| 7 |
|
Excelsior Virton II | 15 | 7 | 2 | 6 | 32:38 | -6 | 23 |
| 8 |
|
Union St. Gilloise II | 15 | 6 | 3 | 6 | 20:17 | 3 | 21 |
| 9 |
|
KVC Westerlo II | 15 | 6 | 2 | 7 | 23:24 | -1 | 20 |
| 10 |
|
Lierse Kempenzonen II | 15 | 5 | 4 | 6 | 20:33 | -13 | 19 |
| 11 |
|
SK Deinze II | 15 | 5 | 2 | 8 | 18:33 | -15 | 17 |
| 12 |
|
RFC Seraing II | 15 | 4 | 0 | 11 | 18:34 | -16 | 12 |
| 13 |
|
Lommel SK II | 15 | 2 | 3 | 10 | 12:36 | -24 | 9 |
| 14 |
|
KV Kortrijk II | 15 | 1 | 4 | 10 | 15:37 | -22 | 7 |
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