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| 24/01/2022 | 18:30 | KAS Eupen II | - | KVC Westerlo II | 3:1 (1:1) | |
| 18:30 | SK Beveren II | - | Royal Excel Mouscron II | 3:2 | ||
| 19:00 | SK Deinze II | - | KV Kortrijk II | 1:1 (0:1) | ||
| 19:00 | Excelsior Virton II | - | K Beerschot VA II | 0:3 (0:2) | ||
| 19:00 | Union St. Gilloise II | - | Lommel SK II | 2:0 (1:0) | ||
| 19:30 | RWDM Brussels FC II | - | KV Oostende II | 0:4 (0:2) | ||
| 07/04/2022 | 15:00 | RFC Seraing II | - | Lierse Kempenzonen II | 5:0 |
| » Tables | Home | Away | First round | Second round |
| # | Team | M. | W | D | L | goals | Dif. | Pt. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
KAS Eupen II | 16 | 12 | 1 | 3 | 41:18 | 23 | 37 |
| 2 |
|
K Beerschot VA II | 16 | 11 | 3 | 2 | 41:15 | 26 | 36 |
| 3 |
|
KV Oostende II | 16 | 8 | 6 | 2 | 40:20 | 20 | 30 |
| 4 |
|
SK Beveren II | 16 | 9 | 1 | 6 | 31:17 | 14 | 28 |
| 5 |
|
RWDM Brussels FC II | 16 | 8 | 2 | 6 | 39:35 | 4 | 26 |
| 6 |
|
Royal Excel Mouscron II | 16 | 7 | 3 | 6 | 31:19 | 12 | 24 |
| 7 |
|
Union St. Gilloise II | 16 | 7 | 3 | 6 | 22:17 | 5 | 24 |
| 8 |
|
Excelsior Virton II | 16 | 7 | 2 | 7 | 32:41 | -9 | 23 |
| 9 |
|
KVC Westerlo II | 16 | 6 | 2 | 8 | 24:27 | -3 | 20 |
| 10 |
|
Lierse Kempenzonen II | 16 | 5 | 4 | 7 | 20:38 | -18 | 19 |
| 11 |
|
SK Deinze II | 16 | 5 | 3 | 8 | 19:34 | -15 | 18 |
| 12 |
|
RFC Seraing II | 16 | 5 | 0 | 11 | 23:34 | -11 | 15 |
| 13 |
|
Lommel SK II | 16 | 2 | 3 | 11 | 12:38 | -26 | 9 |
| 14 |
|
KV Kortrijk II | 16 | 1 | 5 | 10 | 16:38 | -22 | 8 |
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