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| 04/03/2022 | 17:00 | Zrinjski Mostar | - | Radnik Bijeljina | 4:1 (4:0) | |
| 05/03/2022 | 12:00 | FK Rudar | - | Leotar Trebinje | 1:2 (1:0) | |
| 16:00 | Željezničar Sarajevo | - | FK Sarajevo | 2:0 (1:0) | ||
| 06/03/2022 | 12:00 | HŠK Posušje | - | Sloboda Tuzla | 1:0 (1:0) | |
| 14:00 | Borac Banja Luka | - | Velež Mostar | 2:0 (0:0) | ||
| 07/03/2022 | 14:00 | FK Tuzla City | - | Široki Brijeg | 2:2 (0:1) |
| » Tables | Home | Away | First round | Second round |
| # | Team | M. | W | D | L | goals | Dif. | Pt. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Zrinjski Mostar | 21 | 17 | 3 | 1 | 47:9 | 38 | 54 |
| 2 |
|
FK Tuzla City | 21 | 10 | 8 | 3 | 36:23 | 13 | 38 |
| 3 |
|
Borac Banja Luka | 21 | 9 | 9 | 3 | 32:23 | 9 | 36 |
| 4 |
|
FK Sarajevo | 21 | 9 | 4 | 8 | 20:18 | 2 | 31 |
| 5 |
|
Željezničar Sarajevo | 21 | 7 | 8 | 6 | 18:21 | -3 | 29 |
| 6 |
|
Široki Brijeg | 21 | 6 | 10 | 5 | 20:22 | -2 | 28 |
| 7 |
|
Sloboda Tuzla | 21 | 5 | 10 | 6 | 19:18 | 1 | 25 |
| 8 |
|
Velež Mostar | 21 | 7 | 6 | 8 | 25:26 | -1 | 24 |
| 9 |
|
HŠK Posušje | 21 | 4 | 7 | 10 | 17:33 | -16 | 19 |
| 10 |
|
Leotar Trebinje | 21 | 5 | 4 | 12 | 16:34 | -18 | 19 |
| 11 |
|
FK Rudar | 21 | 3 | 7 | 11 | 20:28 | -8 | 16 |
| 12 |
|
Radnik Bijeljina | 21 | 3 | 6 | 12 | 19:34 | -15 | 15 |
| Champions League Quali. | |
| Relegation |
