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| 1st(1st leg) | Rosario Central de Potosí | - | Universitario de Sucre | 0:3 | ||
| 2nd (2nd leg) | Universitario de Sucre | - | Rosario Central de Potosí | 7:2 | ||
| 1st(1st leg): 23/10/2021 20:00 | 2nd (2nd leg): 31/10/2021 23:00 | Winner: Universitario de Sucre | ||||
| 1st(1st leg) | Bermejo | - | Universitario de Vinto | 0:3 | ||
| 2nd (2nd leg) | Universitario de Vinto | - | Bermejo | 2:2 | ||
| 1st(1st leg): 24/10/2021 20:00 | 2nd (2nd leg): 01/11/2021 19:30 | Winner: Universitario de Vinto | ||||
| 1st(1st leg) | Vaca Díez | - | Empresa Minera Huanuni | 2:0 | ||
| 2nd (2nd leg) | Empresa Minera Huanuni | - | Vaca Díez | 1:3 pso | ||
| 1st(1st leg): 24/10/2021 20:00 | 2nd (2nd leg): 30/10/2021 20:00 | Winner: Vaca Díez | ||||
| 1st(1st leg) | Deportivo Shalon | - | Torre Fuerte | 2:1 | ||
| 2nd (2nd leg) | Torre Fuerte | - | Deportivo Shalon | 4:0 | ||
| 1st(1st leg): 24/10/2021 20:00 | 2nd (2nd leg): 30/10/2021 18:00 | Winner: Torre Fuerte | ||||
| 1st(1st leg) | Ciudad Nueva Santa Cruz | - | San Antonio Bulo Bulo | 1:0 | ||
| 2nd (2nd leg) | San Antonio Bulo Bulo | - | Ciudad Nueva Santa Cruz | 2:1 | ||
| 1st(1st leg): 25/10/2021 20:00 | 2nd (2nd leg): 31/10/2021 17:00 | Winner: Ciudad Nueva Santa Cruz | ||||
| 1st(1st leg) | García Agreda | - | Mojocoya | 2:0 | ||
| 2nd (2nd leg) | Mojocoya | - | García Agreda | 2:3 | ||
| 1st(1st leg): 26/10/2021 00:30 | 2nd (2nd leg): 31/10/2021 19:00 | Winner: García Agreda | ||||
