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| 1st(1st leg) | García Agreda | - | Universitario de Sucre | 2:2 | ||
| 2nd (2nd leg) | Universitario de Sucre | - | García Agreda | 4:0 | ||
| 1st(1st leg): 20/11/2021 21:00 | 2nd (2nd leg): 28/11/2021 19:00 | Winner: Universitario de Sucre | ||||
| 1st(1st leg) | Vaca Díez | - | Universitario de Vinto | 0:3 | ||
| 2nd (2nd leg) | Universitario de Vinto | - | Vaca Díez | 4:0 | ||
| 1st(1st leg): 21/11/2021 19:00 | 2nd (2nd leg): 28/11/2021 19:00 | Winner: Universitario de Vinto | ||||
