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| 1st(1st leg) | Nacional Potosí | - | Blooming | 3:1 (2:1) | ||
| 2nd (2nd leg) | Blooming | - | Nacional Potosí | 5:3 (1:0, 2:0, 2:0) pso | ||
| 1st(1st leg): 28/05/2022 20:00 | 2nd (2nd leg): 03/06/2022 01:00 | Winner: Blooming | ||||
| 1st(1st leg) | Always Ready | - | Atlético Palmaflor | 2:1 (1:0) | ||
| 2nd (2nd leg) | Atlético Palmaflor | - | Always Ready | 5:4 (0:0, 2:1, 2:1) pso | ||
| 1st(1st leg): 29/05/2022 20:00 | 2nd (2nd leg): 01/06/2022 21:00 | Winner: Atlético Palmaflor | ||||
| 1st(1st leg) | Royal Pari | - | The Strongest | 0:3 (0:1) | ||
| 2nd (2nd leg) | The Strongest | - | Royal Pari | 4:0 (1:0) | ||
| 1st(1st leg): 29/05/2022 23:00 | 2nd (2nd leg): 02/06/2022 01:30 | Winner: The Strongest | ||||
| 1st(1st leg) | Oriente Petrolero | - | Bolívar | 1:0 (1:0) | ||
| 2nd (2nd leg) | Bolívar | - | Oriente Petrolero | 7:6 (0:0, 1:0, 1:0) pso | ||
| 1st(1st leg): 30/05/2022 00:30 | 2nd (2nd leg): 03/06/2022 01:00 | Winner: Bolívar | ||||
