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| 1st(1st leg) | Iporá - GO | - | Anápolis FC - GO | 1:1 (1:1) | ||
| 2nd (2nd leg) | Anápolis FC - GO | - | Iporá - GO | 0:1 (0:0) | ||
| 1st(1st leg): 09/03/2022 18:30 | 2nd (2nd leg): 13/03/2022 19:00 | Winner: Iporá - GO | ||||
| 1st(1st leg) | CRAC - GO | - | Goiás - GO | 0:3 (0:0) | ||
| 2nd (2nd leg) | Goiás - GO | - | CRAC - GO | 3:0 (0:0) | ||
| 1st(1st leg): 09/03/2022 22:30 | 2nd (2nd leg): 13/03/2022 19:00 | Winner: Goiás - GO | ||||
| 1st(1st leg) | Goianésia - GO | - | Vila Nova - GO | 1:2 (1:1) | ||
| 2nd (2nd leg) | Vila Nova - GO | - | Goianésia - GO | 3:1 (1:1) | ||
| 1st(1st leg): 09/03/2022 23:00 | 2nd (2nd leg): 12/03/2022 19:30 | Winner: Vila Nova - GO | ||||
| 1st(1st leg) | Morrinhos - GO | - | Atlético Goianiense | 0:1 (0:0) | ||
| 2nd (2nd leg) | Atlético Goianiense | - | Morrinhos - GO | 3:0 (1:0) | ||
| 1st(1st leg): 09/03/2022 23:30 | 2nd (2nd leg): 12/03/2022 19:30 | Winner: Atlético Goianiense | ||||
