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| 1st(1st leg) | Cruzeiro | - | Athletic - MG | 2:0 (1:0) | ||
| 2nd (2nd leg) | Athletic - MG | - | Cruzeiro | 1:2 (1:2) | ||
| 1st(1st leg): 22/03/2022 23:30 | 2nd (2nd leg): 26/03/2022 19:30 | Winner: Cruzeiro | ||||
| 1st(1st leg) | Caldense - MG | - | Atlético Mineiro | 0:2 (0:2) | ||
| 2nd (2nd leg) | Atlético Mineiro | - | Caldense - MG | 3:0 (2:0) | ||
| 1st(1st leg): 23/03/2022 19:30 | 2nd (2nd leg): 27/03/2022 22:00 | Winner: Atlético Mineiro | ||||
