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| 1st(1st leg) | Cascavel FC - PR | - | Maringá - PR | 0:1 (0:0) | ||
| 2nd (2nd leg) | Maringá - PR | - | Cascavel FC - PR | 5:0 (3:0) | ||
| 1st(1st leg): 12/03/2022 21:30 | 2nd (2nd leg): 20/03/2022 21:30 | Winner: Maringá - PR | ||||
| 1st(1st leg) | Londrina - PR | - | Athletico Paranaense | 1:0 (1:0) | ||
| 2nd (2nd leg) | Athletico Paranaense | - | Londrina - PR | 4:2 (1:0, 2:1, 2:1) pso | ||
| 1st(1st leg): 13/03/2022 14:00 | 2nd (2nd leg): 20/03/2022 19:00 | Winner: Athletico Paranaense | ||||
| 1st(1st leg) | Independente - PR | - | Operário Ferroviário - PR | 2:1 (2:0) | ||
| 2nd (2nd leg) | Operário Ferroviário - PR | - | Independente - PR | 2:0 (1:0) | ||
| 1st(1st leg): 13/03/2022 18:30 | 2nd (2nd leg): 19/03/2022 21:30 | Winner: Operário Ferroviário - PR | ||||
| 1st(1st leg) | Cianorte - PR | - | Coritiba - PR | 0:1 (0:1) | ||
| 2nd (2nd leg) | Coritiba - PR | - | Cianorte - PR | 3:0 (1:0) | ||
| 1st(1st leg): 13/03/2022 21:30 | 2nd (2nd leg): 19/03/2022 19:00 | Winner: Coritiba - PR | ||||
