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| 1st(1st leg) | Santa Fe | - | Deportes Tolima | 1:2 (0:2) | ||
| 2nd (2nd leg) | Deportes Tolima | - | Santa Fe | 4:3 (0:1, 0:1) pso | ||
| 1st(1st leg): 15/11/2018 01:00 | 2nd (2nd leg): 18/11/2018 01:00 | Winner: Deportes Tolima | ||||
| 1st(1st leg) | Independiente Medellín | - | Atlético Bucaramanga | 3:0 (2:0) | ||
| 2nd (2nd leg) | Atlético Bucaramanga | - | Independiente Medellín | 2:0 (1:0) | ||
| 1st(1st leg): 15/11/2018 01:00 | 2nd (2nd leg): 17/11/2018 23:00 | Winner: Independiente Medellín | ||||
| 1st(1st leg) | Águilas Doradas | - | Once Caldas | 1:0 (0:0) | ||
| 2nd (2nd leg) | Once Caldas | - | Águilas Doradas | 1:1 (1:1) | ||
| 1st(1st leg): 16/11/2018 00:00 | 2nd (2nd leg): 18/11/2018 22:15 | Winner: Águilas Doradas | ||||
| 1st(1st leg) | Atlético Junior | - | La Equidad | 1:0 (0:0) | ||
| 2nd (2nd leg) | La Equidad | - | Atlético Junior | 0:0 (0:0) | ||
| 1st(1st leg): 16/11/2018 01:00 | 2nd (2nd leg): 19/11/2018 00:30 | Winner: Atlético Junior | ||||
