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| 1st(1st leg) | La Equidad | - | Santa Fe | 1:1 (0:1) | ||
| 2nd (2nd leg) | Santa Fe | - | La Equidad | 2:1 (1:0) | ||
| 1st(1st leg): 06/12/2020 01:00 | 2nd (2nd leg): 13/12/2020 00:30 | Winner: Santa Fe | ||||
| 1st(1st leg) | América de Cali | - | Atlético Junior | 0:0 (0:0) | ||
| 2nd (2nd leg) | Atlético Junior | - | América de Cali | 1:2 (0:2) | ||
| 1st(1st leg): 07/12/2020 01:00 | 2nd (2nd leg): 14/12/2020 01:00 | Winner: América de Cali | ||||
