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| 1st(1st leg) | América de Cali | - | Millonarios | 1:2 (0:1) | ||
| 2nd (2nd leg) | Millonarios | - | América de Cali | 0:0 (0:0) | ||
| 1st(1st leg): 24/04/2021 21:30 | 2nd (2nd leg): 02/05/2021 00:00 | Winner: Millonarios | ||||
| 1st(1st leg) | Atlético Junior | - | Santa Fe | 3:1 (1:0) | ||
| 2nd (2nd leg) | Santa Fe | - | Atlético Junior | 0:0 (0:0) | ||
| 1st(1st leg): 25/04/2021 21:30 | 2nd (2nd leg): 02/05/2021 19:00 | Winner: Atlético Junior | ||||
| 1st(1st leg) | Deportes Tolima | - | Deportivo Cali | 3:0 (1:0) | ||
| 2nd (2nd leg) | Deportivo Cali | - | Deportes Tolima | 2:0 (2:0) | ||
| 1st(1st leg): 25/04/2021 23:40 | 2nd (2nd leg): 04/06/2021 21:30 | Winner: Deportes Tolima | ||||
| 1st(1st leg) | La Equidad | - | Atlético Nacional | 1:0 (0:0) | ||
| 2nd (2nd leg) | Atlético Nacional | - | La Equidad | 2:2 (0:0) | ||
| 1st(1st leg): 26/04/2021 02:00 | 2nd (2nd leg): 02/05/2021 21:30 | Winner: La Equidad | ||||
