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| 1st(1st leg) | Árabe Unido | - | Arnett Gardens | 3:0 (0:0) | ||
| 2nd (2nd leg) | Arnett Gardens | - | Árabe Unido | 2:1 (1:1) | ||
| 1st(1st leg): 01/08/2018 01:00 | 2nd (2nd leg): 10/08/2018 03:00 | Winner: Árabe Unido | ||||
| 1st(1st leg) | Motagua | - | Belmopan Bandits | 2:0 (0:0) | ||
| 2nd (2nd leg) | Belmopan Bandits | - | Motagua | 0:1 (0:0) | ||
| 1st(1st leg): 01/08/2018 03:00 | 2nd (2nd leg): 08/08/2018 01:00 | Winner: Motagua | ||||
| 1st(1st leg) | FAS | - | Municipal Pérez Zeledón | 2:1 (0:1) | ||
| 2nd (2nd leg) | Municipal Pérez Zeledón | - | FAS | 1:1 (0:0) | ||
| 1st(1st leg): 01/08/2018 03:00 | 2nd (2nd leg): 08/08/2018 03:00 | Winner: FAS | ||||
| 1st(1st leg) | Club Franciscain | - | CD Walter Ferretti | 1:0 (0:0) | ||
| 2nd (2nd leg) | CD Walter Ferretti | - | Club Franciscain | 4:1 (0:0, 1:0) pso | ||
| 1st(1st leg): 02/08/2018 01:00 | 2nd (2nd leg): 09/08/2018 01:00 | Winner: CD Walter Ferretti | ||||
| 1st(1st leg) | Diriangén FC | - | UD Universitario | 0:4 (0:0) | ||
| 2nd (2nd leg) | UD Universitario | - | Diriangén FC | 3:1 (2:0) | ||
| 1st(1st leg): 02/08/2018 01:00 | 2nd (2nd leg): 08/08/2018 01:00 | Winner: UD Universitario | ||||
| 1st(1st leg) | Santos de Guápiles | - | Portmore United | 1:2 (0:2) | ||
| 2nd (2nd leg) | Portmore United | - | Santos de Guápiles | 7:6 (1:2, 1:2) pso | ||
| 1st(1st leg): 02/08/2018 03:00 | 2nd (2nd leg): 10/08/2018 00:30 | Winner: Portmore United | ||||
| 1st(1st leg) | Tauro FC | - | Real España | 1:0 (0:0) | ||
| 2nd (2nd leg) | Real España | - | Tauro FC | 1:1 (1:1) | ||
| 1st(1st leg): 03/08/2018 01:00 | 2nd (2nd leg): 10/08/2018 03:00 | Winner: Tauro FC | ||||
| 1st(1st leg) | CS Herediano | - | Santa Tecla FC | 1:0 (1:0) | ||
| 2nd (2nd leg) | Santa Tecla FC | - | CS Herediano | 2:1 (2:1) | ||
| 1st(1st leg): 03/08/2018 03:00 | 2nd (2nd leg): 09/08/2018 03:00 | Winner: CS Herediano | ||||
