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| 1st(1st leg) | FAS | - | Árabe Unido | 0:1 (0:0) | ||
| 2nd (2nd leg) | Árabe Unido | - | FAS | 3:1 (0:1) | ||
| 1st(1st leg): 22/08/2018 03:00 | 2nd (2nd leg): 29/08/2018 03:00 | Winner: Árabe Unido | ||||
| 1st(1st leg) | CS Herediano | - | UD Universitario | 3:0 (1:0) | ||
| 2nd (2nd leg) | UD Universitario | - | CS Herediano | 1:2 (0:0) | ||
| 1st(1st leg): 23/08/2018 03:00 | 2nd (2nd leg): 30/08/2018 03:00 | Winner: CS Herediano | ||||
| 1st(1st leg) | Tauro FC | - | CD Walter Ferretti | 3:1 (2:1) | ||
| 2nd (2nd leg) | CD Walter Ferretti | - | Tauro FC | 0:4 (0:2) | ||
| 1st(1st leg): 24/08/2018 01:00 | 2nd (2nd leg): 31/08/2018 01:00 | Winner: Tauro FC | ||||
| 1st(1st leg) | Motagua | - | Portmore United | 3:2 (2:0) | ||
| 2nd (2nd leg) | Portmore United | - | Motagua | 0:2 (0:1) | ||
| 1st(1st leg): 24/08/2018 03:00 | 2nd (2nd leg): 31/08/2018 03:00 | Winner: Motagua | ||||
