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| 1st(1st leg) | Orense SC | - | Delfin SC | 1:0 (1:0) | ||
| 2nd (2nd leg) | Delfin SC | - | Orense SC | 3:0 (1:0, 2:1, 2:1) pso | ||
| 1st(1st leg): 19/08/2022 17:00 | 2nd (2nd leg): 26/08/2022 15:00 | Winner: Delfin SC | ||||
| 1st(1st leg) | Manta FC | - | Emelec | 1:2 (1:0) | ||
| 2nd (2nd leg) | Emelec | - | Manta FC | 8:6 (0:0, 0:1, 0:1) pso | ||
| 1st(1st leg): 19/08/2022 19:00 | 2nd (2nd leg): 27/08/2022 21:30 | Winner: Emelec | ||||
| 1st(1st leg) | Macará | - | Cumbayá | 2:2 (1:1) | ||
| 2nd (2nd leg) | Cumbayá | - | Macará | 5:4 (0:0, 0:0, 0:0) pso | ||
| 1st(1st leg): 20/08/2022 16:00 | 2nd (2nd leg): 27/08/2022 15:00 | Winner: Cumbayá | ||||
| 1st(1st leg) | Aucas | - | Mushuc Runa | 4:3 (4:2) | ||
| 2nd (2nd leg) | Mushuc Runa | - | Aucas | 4:2 (1:0, 2:1, 2:1) pso | ||
| 1st(1st leg): 20/08/2022 17:00 | 2nd (2nd leg): 27/08/2022 15:30 | Winner: Mushuc Runa | ||||
| 1st(1st leg) | Universidad Catolica | - | Barcelona | 1:1 (1:1) | ||
| 2nd (2nd leg) | Barcelona | - | Universidad Catolica | 5:1 (3:1) | ||
| 1st(1st leg): 20/08/2022 17:00 | 2nd (2nd leg): 27/08/2022 19:00 | Winner: Barcelona | ||||
| 1st(1st leg) | 9 de Octubre | - | Independiente del Valle | 1:4 (0:3) | ||
| 2nd (2nd leg) | Independiente del Valle | - | 9 de Octubre | 3:0 dec. | ||
| 1st(1st leg): 20/08/2022 18:15 | 2nd (2nd leg): 27/08/2022 16:00 | Winner: Independiente del Valle | ||||
| 1st(1st leg) | Olmedo | - | Búhos ULVR | 0:2 (0:0) | ||
| 2nd (2nd leg) | Búhos ULVR | - | Olmedo | 9:0 (4:0) | ||
| 1st(1st leg): 21/08/2022 18:00 | 2nd (2nd leg): 27/08/2022 17:00 | Winner: Búhos ULVR | ||||
| 1st(1st leg) | LDU Quito | - | El Nacional | 3:2 (1:1) | ||
| 2nd (2nd leg) | El Nacional | - | LDU Quito | 1:1 (0:1) | ||
| 1st(1st leg): 21/08/2022 21:15 | 2nd (2nd leg): 27/08/2022 17:30 | Winner: LDU Quito | ||||
