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| 1st(1st leg) | Volos NFC | - | OFI Heraklion | 2:0 (0:0) | ||
| 2nd (2nd leg) | OFI Heraklion | - | Volos NFC | 1:1 (1:1) | ||
| 1st(1st leg): 20/01/2021 13:00 | 2nd (2nd leg): 04/02/2021 13:00 | Winner: Volos NFC | ||||
| 1st(1st leg) | Aris Saloniki | - | Asteras Tripolis | 2:0 (0:0) | ||
| 2nd (2nd leg) | Asteras Tripolis | - | Aris Saloniki | 0:2 (0:1) | ||
| 1st(1st leg): 20/01/2021 13:00 | 2nd (2nd leg): 04/02/2021 15:15 | Winner: Aris Saloniki | ||||
| 1st(1st leg) | PAOK Saloniki | - | AE Lárissa | 5:0 (2:0) | ||
| 2nd (2nd leg) | AE Lárissa | - | PAOK Saloniki | 1:2 (1:2) | ||
| 1st(1st leg): 20/01/2021 15:15 | 2nd (2nd leg): 03/02/2021 17:30 | Winner: PAOK Saloniki | ||||
| 1st(1st leg) | Panetolikos | - | Olympiakos Piraeus | 0:3 (0:1) | ||
| 2nd (2nd leg) | Olympiakos Piraeus | - | Panetolikos | 3:0 (2:0) | ||
| 1st(1st leg): 20/01/2021 17:30 | 2nd (2nd leg): 03/02/2021 15:15 | Winner: Olympiakos Piraeus | ||||
| 1st(1st leg) | AEK Athen | - | Apollon Smyrnis | 2:0 (1:0) | ||
| 2nd (2nd leg) | Apollon Smyrnis | - | AEK Athen | 2:1 (2:1) | ||
| 1st(1st leg): 20/01/2021 19:30 | 2nd (2nd leg): 04/02/2021 17:30 | Winner: AEK Athen | ||||
| 1st(1st leg) | PAS Giannina | - | Atromitos | 2:2 (1:2) | ||
| 2nd (2nd leg) | Atromitos | - | PAS Giannina | 2:3 (1:3) | ||
| 1st(1st leg): 21/01/2021 17:30 | 2nd (2nd leg): 03/02/2021 13:00 | Winner: PAS Giannina | ||||
