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| 27/10/2018 | 16:00 | CS Bourscheid | - | CS FOLA Esch | 1:16 | ||
| 17:00 | UN Käerjéng | - | Jeunesse Esch | 0:5 | |||
| 28/10/2018 | 15:00 | US Mertert/Wasserbillig | - | Koeppchen Wormeldange | 5:1 | ||
| 15:00 | Progrès Niedercorn | - | US Hostert | 1:0 | |||
| 15:00 | US Sandweiler | - | F91 Dudelange | 0:6 | |||
| 15:00 | US Esch | - | Union Titus Pétange | 2:1 aet | |||
| 15:00 | FC 72 Erpeldange | - | RM Hamm Benfica | 2:6 aet | |||
| 15:00 | Jeunesse Canach | - | FC Atert Bissen | 0:2 | |||
| 15:00 | FC Mamer 32 | - | Blue Boys Muhlenbach | 0:1 | |||
| 15:00 | CeBra 01 | - | Etzella Ettelbruck | 0:2 | |||
| 15:00 | Sporting Bertrange | - | Alliance Aischdall | 3:2 | |||
| 15:00 | Swift Hesperange | - | US Mondorf | 1:3 | |||
| 15:00 | RFCU Luxemburg | - | FC Differdange 03 | 4:5 pso | |||
| 15:00 | FC Rodange 91 | - | Victoria Rosport | 8:9 pso | |||
| 15:00 | Union 05 Kayl-Tétange | - | FC Wiltz 71 | 3:4 pso | |||
| 17:00 | US Rumelange | - | UNA Strassen | 1:4 |
