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| 1st(1st leg) | FC Grănicerul | - | FC Milsami | 0:2 | ||
| 2nd (2nd leg) | FC Milsami | - | FC Grănicerul | 4:2 | ||
| 1st(1st leg): 20/06/2018 16:30 | 2nd (2nd leg): 05/07/2018 18:00 | Winner: FC Milsami | ||||
| 1st(1st leg) | FC Sfîntul Gheorghe | - | CSF Sparta | 7:2 | ||
| 2nd (2nd leg) | CSF Sparta | - | FC Sfîntul Gheorghe | 3:3 | ||
| 1st(1st leg): 20/06/2018 16:30 | 2nd (2nd leg): 07/07/2018 15:30 | Winner: FC Sfîntul Gheorghe | ||||
| 1st(1st leg) | FC Cahul 2005 | - | Dinamo-Auto | 1:0 | ||
| 2nd (2nd leg) | Dinamo-Auto | - | FC Cahul 2005 | 5:0 | ||
| 1st(1st leg): 20/06/2018 16:30 | 2nd (2nd leg): 07/07/2018 15:30 | Winner: Dinamo-Auto | ||||
| 1st(1st leg) | Victoria Bardar | - | FC Zaria | 1:4 | ||
| 2nd (2nd leg) | FC Zaria | - | Victoria Bardar | 4:1 | ||
| 1st(1st leg): 20/06/2018 16:30 | 2nd (2nd leg): 06/07/2018 15:30 | Winner: FC Zaria | ||||
| 1st(1st leg) | Speranţa Nisporeni | - | FC Codru Lozova | 0:1 | ||
| 2nd (2nd leg) | FC Codru Lozova | - | Speranţa Nisporeni | 1:2 | ||
| 1st(1st leg): 20/06/2018 16:30 | 2nd (2nd leg): 07/07/2018 15:30 | Winner: Speranţa Nisporeni | ||||
| 1st(1st leg) | FC Sheriff | - | FC Iskra-Stal | 7:0 | ||
| 2nd (2nd leg) | FC Iskra-Stal | - | FC Sheriff | 1:9 | ||
| 1st(1st leg): 20/06/2018 17:00 | 2nd (2nd leg): 05/07/2018 15:30 | Winner: FC Sheriff | ||||
| 1st(1st leg) | FC Zimbru | - | CSF Sparta II | 0:0 | ||
| 2nd (2nd leg) | CSF Sparta II | - | FC Zimbru | 1:4 | ||
| 1st(1st leg): 20/06/2018 17:00 | 2nd (2nd leg): 07/07/2018 15:30 | Winner: FC Zimbru | ||||
| 1st(1st leg) | CS Petrocub | - | FC Floreşti | 10:2 | ||
| 2nd (2nd leg) | FC Floreşti | - | CS Petrocub | 1:6 | ||
| 1st(1st leg): 20/06/2018 18:00 | 2nd (2nd leg): 06/07/2018 15:30 | Winner: CS Petrocub | ||||
