1st(1st leg) Dinamo Auto - FC Sfîntul Gheorghe 0:3 (0:2)
2nd (2nd leg) FC Sfîntul Gheorghe - Dinamo Auto 1:2 (1:1)
1st(1st leg): 26/09/2018 13:30 2nd (2nd leg): 31/10/2018 11:00 Winner: FC Sfîntul Gheorghe
1st(1st leg) FC Zaria - FC Zimbru 3:2 (0:1)
2nd (2nd leg) FC Zimbru - FC Zaria 7:1 (3:0)
1st(1st leg): 26/09/2018 13:30 2nd (2nd leg): 31/10/2018 11:00 Winner: FC Zimbru
1st(1st leg) FC Sheriff - Speranţa Nisporeni 3:0 (2:0)
2nd (2nd leg) Speranţa Nisporeni - FC Sheriff 0:3 (0:0)
1st(1st leg): 26/09/2018 16:00 2nd (2nd leg): 31/10/2018 11:00 Winner: FC Sheriff
1st(1st leg) CS Petrocub - FC Milsami 0:2 (0:1)
2nd (2nd leg) FC Milsami - CS Petrocub 0:1 (0:0)
1st(1st leg): 26/09/2018 16:30 2nd (2nd leg): 31/10/2018 16:00 Winner: FC Milsami