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| 27/10/2020 | 11:00 | FC Milsami | - | Victoria Bardar | 7:1 | |
| 16:00 | FC Codru Lozova | - | FC Cahul 2005 | 1:0 | ||
| 28/10/2020 | 11:00 | FC Zimbru | - | FC Floreşti | 0:1 | |
| 11:00 | CS Petrocub | - | CF Ungheni | 4:1 | ||
| 11:00 | Dinamo-Auto | - | Sokol Copceac | 13:0 | ||
| 11:00 | Sporting Trestieni | - | FC Sfîntul Gheorghe | 0:4 | ||
| 11:00 | Speranţa Nisporeni | - | Dacia Buiucani | 2:1 aet | ||
| 13:00 | FC Sheriff | - | FC Iskra-Stal | 2:1 |
