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| 1st(1st leg) | Pumas UNAM | - | CF Monterrey | 1:2 (0:0) | ||
| 2nd (2nd leg) | CF Monterrey | - | Pumas UNAM | 3:0 (2:0) | ||
| 1st(1st leg): 24/04/2019 22:00 | 2nd (2nd leg): 28/04/2019 03:06 | Winner: CF Monterrey | ||||
| 1st(1st leg) | Atlas Guadalajara | - | CF Pachuca | 0:1 (0:0) | ||
| 2nd (2nd leg) | CF Pachuca | - | Atlas Guadalajara | 1:1 (0:0) | ||
| 1st(1st leg): 25/04/2019 23:00 | 2nd (2nd leg): 30/04/2019 01:00 | Winner: CF Pachuca | ||||
| 1st(1st leg) | Puebla FC | - | UANL Tigres | 1:2 (0:0) | ||
| 2nd (2nd leg) | UANL Tigres | - | Puebla FC | 2:0 (0:0) | ||
| 1st(1st leg): 26/04/2019 01:00 | 2nd (2nd leg): 30/04/2019 02:00 | Winner: UANL Tigres | ||||
| 1st(1st leg) | Club León | - | CF América | 0:1 (0:0) | ||
| 2nd (2nd leg) | CF América | - | Club León | 1:1 (0:1) | ||
| 1st(1st leg): 26/04/2019 03:00 | 2nd (2nd leg): 28/04/2019 22:00 | Winner: CF América | ||||
