 |
 |
|
|
| 12/03/2022 | 18:00 | Cruz Azul | - | Santos Laguna | 2:3 (1:2) | |
| 13/03/2022 | 01:00 | CF Pachuca | - | Atlético San Luis | 2:0 (2:0) | |
| 02:00 | Mazatlán FC | - | Club León | 0:0 (0:0) | ||
| 18:00 | Puebla FC | - | FC Juárez | 2:1 (1:1) | ||
| 14/03/2022 | 03:00 | CF América | - | Deportivo Guadalajara | 1:2 (1:0) | |
| 23:00 | Deportivo Toluca | - | UANL Tigres | 2:2 (1:0) | ||
| 15/03/2022 | 01:00 | CF Monterrey | - | Club Necaxa | 5:2 (4:1) | |
| 03:00 | Club Tijuana | - | Pumas UNAM | 0:0 (0:0) | ||
| 07/04/2022 | 23:00 | Gallos Blancos | - | Atlas Guadalajara | 1:3 (0:2) |
| » Tables | Home | Away | First round | Second round |
| # | Team | M. | W | D | L | goals | Dif. | Pt. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
CF Monterrey | 10 | 10 | 0 | 0 | 39:8 | 31 | 30 |
| 2 |
|
CF América | 10 | 7 | 1 | 2 | 23:8 | 15 | 22 |
| 3 |
|
UANL Tigres | 10 | 6 | 4 | 0 | 21:9 | 12 | 22 |
| 4 |
|
Deportivo Guadalajara | 10 | 6 | 4 | 0 | 16:5 | 11 | 22 |
| 5 |
|
CF Pachuca | 10 | 6 | 1 | 3 | 17:10 | 7 | 19 |
| 6 |
|
Atlas Guadalajara | 10 | 4 | 4 | 2 | 17:16 | 1 | 16 |
| 7 |
|
Pumas UNAM | 10 | 3 | 3 | 4 | 10:10 | 0 | 12 |
| 8 |
|
Deportivo Toluca | 10 | 3 | 3 | 4 | 16:18 | -2 | 12 |
| 9 |
|
Gallos Blancos | 10 | 3 | 3 | 4 | 9:15 | -6 | 12 |
| 10 |
|
Atlético San Luis | 10 | 2 | 5 | 3 | 11:14 | -3 | 11 |
| 11 |
|
Club Tijuana | 10 | 1 | 7 | 2 | 13:19 | -6 | 10 |
| 12 |
|
Puebla FC | 10 | 3 | 1 | 6 | 9:16 | -7 | 10 |
| 13 |
|
Cruz Azul | 10 | 2 | 3 | 5 | 11:16 | -5 | 9 |
| 14 |
|
Mazatlán FC | 10 | 2 | 3 | 5 | 8:17 | -9 | 9 |
| 15 |
|
Club León | 10 | 2 | 3 | 5 | 11:21 | -10 | 9 |
| 16 |
|
Club Necaxa | 10 | 2 | 3 | 5 | 10:20 | -10 | 9 |
| 17 |
|
Santos Laguna | 10 | 2 | 1 | 7 | 7:18 | -11 | 7 |
| 18 |
|
FC Juárez | 10 | 1 | 1 | 8 | 9:17 | -8 | 4 |
| Playoffs |
