 |
 |
|
|
| 20/03/2022 | 23:00 | Atlético San Luis | - | Santos Laguna | 2:4 (1:2) | |
| 23:00 | Gallos Blancos | - | Club Necaxa | 3:0 (2:0) | ||
| 21/03/2022 | 18:00 | Atlas Guadalajara | - | FC Juárez | 2:1 (1:0) | |
| 18:00 | Cruz Azul | - | CF Pachuca | 0:2 (0:1) | ||
| 23:00 | Deportivo Toluca | - | CF América | 0:4 (0:2) | ||
| 22/03/2022 | 01:00 | Deportivo Guadalajara | - | Puebla FC | 1:0 (1:0) | |
| 01:00 | UANL Tigres | - | Club León | 6:0 (4:0) | ||
| 02:00 | Mazatlán FC | - | Pumas UNAM | 0:2 (0:1) | ||
| 03:00 | Club Tijuana | - | CF Monterrey | 2:0 (0:0) |
| » Tables | Home | Away | First round | Second round |
| # | Team | M. | W | D | L | goals | Dif. | Pt. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
CF Monterrey | 12 | 11 | 0 | 1 | 40:10 | 30 | 33 |
| 2 |
|
CF América | 12 | 9 | 1 | 2 | 31:9 | 22 | 28 |
|
UANL Tigres | 12 | 8 | 4 | 0 | 31:9 | 22 | 28 | |
| 4 |
|
Deportivo Guadalajara | 12 | 8 | 4 | 0 | 20:5 | 15 | 28 |
| 5 |
|
CF Pachuca | 12 | 8 | 1 | 3 | 20:10 | 10 | 25 |
| 6 |
|
Atlas Guadalajara | 12 | 5 | 5 | 2 | 19:17 | 2 | 20 |
| 7 |
|
Pumas UNAM | 12 | 4 | 4 | 4 | 12:10 | 2 | 16 |
| 8 |
|
Gallos Blancos | 12 | 4 | 3 | 5 | 13:19 | -6 | 15 |
| 9 |
|
Deportivo Toluca | 12 | 3 | 4 | 5 | 18:24 | -6 | 13 |
| 10 |
|
Club Tijuana | 12 | 2 | 7 | 3 | 15:22 | -7 | 13 |
| 11 |
|
Club León | 12 | 3 | 3 | 6 | 13:27 | -14 | 12 |
| 12 |
|
Atlético San Luis | 12 | 2 | 5 | 5 | 13:19 | -6 | 11 |
| 13 |
|
Santos Laguna | 12 | 3 | 1 | 8 | 11:21 | -10 | 10 |
| 14 |
|
Puebla FC | 12 | 3 | 1 | 8 | 9:19 | -10 | 10 |
| 15 |
|
Mazatlán FC | 12 | 2 | 4 | 6 | 9:20 | -11 | 10 |
| 16 |
|
Club Necaxa | 12 | 2 | 4 | 6 | 12:25 | -13 | 10 |
| 17 |
|
Cruz Azul | 12 | 2 | 3 | 7 | 11:22 | -11 | 9 |
| 18 |
|
FC Juárez | 12 | 1 | 2 | 9 | 11:20 | -9 | 5 |
| Playoffs |
