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| 1st(1st leg) | CF América | - | Deportivo Guadalajara | 3:1 (1:0) | ||
| 2nd (2nd leg) | Deportivo Guadalajara | - | CF América | 3:3 (0:1) | ||
| 1st(1st leg): 05/11/2022 00:00 | 2nd (2nd leg): 08/11/2022 01:00 | Winner: CF América | ||||
| 1st(1st leg) | UANL Tigres | - | CF Monterrey | 2:1 (2:0) | ||
| 2nd (2nd leg) | CF Monterrey | - | UANL Tigres | 2:2 (1:1) | ||
| 1st(1st leg): 05/11/2022 02:06 | 2nd (2nd leg): 08/11/2022 03:06 | Winner: UANL Tigres | ||||
