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| 1st(1st leg) | Cruz Azul | - | Deportivo Guadalajara | 0:1 (0:0) | ||
| 2nd (2nd leg) | Deportivo Guadalajara | - | Cruz Azul | 1:1 (1:0) | ||
| 1st(1st leg): 27/10/2022 22:00 | 2nd (2nd leg): 30/10/2022 22:40 | Winner: Deportivo Guadalajara | ||||
| 1st(1st leg) | CF Pachuca | - | CF Monterrey | 2:1 (0:0) | ||
| 2nd (2nd leg) | CF Monterrey | - | CF Pachuca | 4:0 (1:0) | ||
| 1st(1st leg): 28/10/2022 23:05 | 2nd (2nd leg): 01/11/2022 03:00 | Winner: CF Monterrey | ||||
| 1st(1st leg) | Deportivo Toluca | - | UANL Tigres | 0:4 (0:3) | ||
| 2nd (2nd leg) | UANL Tigres | - | Deportivo Toluca | 5:0 (2:0) | ||
| 1st(1st leg): 29/10/2022 01:00 | 2nd (2nd leg): 01/11/2022 01:00 | Winner: UANL Tigres | ||||
| 1st(1st leg) | Club Tijuana | - | CF América | 0:1 (0:1) | ||
| 2nd (2nd leg) | CF América | - | Club Tijuana | 2:0 (1:0) | ||
| 1st(1st leg): 29/10/2022 03:06 | 2nd (2nd leg): 31/10/2022 23:00 | Winner: CF América | ||||
