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| 1st(1st leg) | Leones Negros | - | FC Juárez | 1:1 (0:0) | ||
| 2nd (2nd leg) | FC Juárez | - | Leones Negros | 1:1 (0:0) | ||
| 1st(1st leg): 15/11/2018 01:00 | 2nd (2nd leg): 18/11/2018 03:00 | |||||
| 1st(1st leg) | Dorados de Sinaloa | - | Mineros de Zacatecas | 0:0 (0:0) | ||
| 2nd (2nd leg) | Mineros de Zacatecas | - | Dorados de Sinaloa | 0:1 (0:0) | ||
| 1st(1st leg): 15/11/2018 03:00 | 2nd (2nd leg): 17/11/2018 22:00 | Winner: Dorados de Sinaloa | ||||
| 1st(1st leg) | Alebrijes de Oaxaca | - | Atlante | 1:1 (1:1) | ||
| 2nd (2nd leg) | Atlante | - | Alebrijes de Oaxaca | 0:0 (0:0) | ||
| 1st(1st leg): 16/11/2018 01:00 | 2nd (2nd leg): 19/11/2018 01:00 | Winner: Atlante | ||||
| 1st(1st leg) | Atlético San Luis | - | Cimarrones de Sonora | 0:0 (0:0) | ||
| 2nd (2nd leg) | Cimarrones de Sonora | - | Atlético San Luis | 1:3 (0:2) | ||
| 1st(1st leg): 16/11/2018 03:00 | 2nd (2nd leg): 19/11/2018 03:00 | Winner: Atlético San Luis | ||||
